Inlägg

Visar inlägg från januari, 2023

Sällfors

Solnedgång …

Högre och högre …

Vinprovning Gamle Port

Red

Arinto Dos Açores( Antonio Macanita )

Uffe W håller låda …

"The ability to speak several languages is an asset, but the ability to keep your mouth closed in any language is priceless." Anonymous

Blomster …

Harmoni …

Mendel( Cabernet Sauvignon )

Ett steg i taget …

Fake?

"Both optimists and pessimists contribute to society. The optimist invents the airplane, the pessimist the parachute." - George Bernard Shaw

The Texas A&M School of Medicine bragged that removing photos of white male alumni was an example of its institutional commitment to diversity, equity, and inclusion , new documents reveal. - Washington Examanier

Stora blå( Sjöfartsmuseet )

El Muelle( Palomino Fino )

Ek & Janson

Infant?

RNA vaccines are efficient preventive measures to combat the SARS-CoV-2 pandemic. High levels of neutralizing SARS-CoV-2-antibodies are an important component of vaccine-induced immunity. Shortly after the initial two mRNA vaccine doses, the IgG response mainly consists of the pro-inflammatory subclasses IgG1 and IgG3. Here, we report that several months after the second vaccination, SARS-CoV-2-specific antibodies were increasingly composed of non-inflammatory IgG4, which were further boosted by a third mRNA vaccination and/or SARS-CoV-2 variant breakthrough infections. IgG4 antibodies among all spike-specific IgG antibodies rose on average from 0.04% shortly after the second vaccination to 19.27% late after the third vaccination. This induction of IgG4 antibodies was not observed after homologous or heterologous SARS-CoV-2 vaccination with adenoviral vectors. Single-cell sequencing and flow cytometry revealed substantial frequencies of IgG4-switched B cells within the spike-binding memory B-cell population (median 14.4%; interquartile range (IQR) 6.7–18.1%) compared to the overall memory B-cell repertoire (median 1.3%; IQR 0.9–2.2%) after three immunizations. Importantly, this class switch was associated with a reduced capacity of the spike-specific antibodies to mediate antibody-dependent cellular phagocytosis and complement deposition. Since Fc-mediated effector functions are critical for antiviral immunity, these findings may have consequences for the choice and timing of vaccination regimens using mRNA vaccines, including future booster immunizations against SARS-CoV-2. - Science

Sancerre Les Baronnes( Sauvignon blanc )

Bourgogne Cuvée Margot( Pinot Noir )

"When a thing is funny, search it for a hidden truth." - G B Shaw

Till Årets förvillare 2022 utses Expressen och Aftonbladet ...

Tur att dina barn inte upptäckte vem som stod för ondskan, du själv ...

kan man inte deala med skurkarna blir man blåst

Att föregå med gott exempel ...

Chat GPT

London

Alkoholfri

Ikea + egen design …

Böjlig is …

”oberoende socialdemokratisk”, men nyhetsredaktionen har ingen politisk färg. På Aftonbladet skiljer vi på nyhetsjournalistiken och åsiktsjournalistiken.( ? )

Korruption förekommer vid uppemot var tionde upphandling, enligt Konkurrensverket som nyligen delat ut sin första bot. Otillåtna direktupphandlingar förekommer överallt enligt myndighetens generaldirektör. ”I lågkonjunktur är det extra viktigt att säkerställa att reglerna följs”, säger Rikard Jermsten, Konkurrensverket, till Di.

Vem?

Härlig variation …

L’orange

"Most New Year's resolutions go in one year and out the other!"

”Ta bort algoritmerna på sociala medier” - Babben Larsson inför 2023( DI Weekend )

218 dagar kvar …

The purpose of this study was to evaluate whether a bivalent COVID-19 vaccine protects against COVID-19.

Smörstekt brioche, smetana, picklad rödlök, skagenröra, morotssoppa/räkor, oxfilé, sidfläsk, svamp, syltlök, madeirasky, grönkål, potatispuré, pannacotta, havtorn, maräng och mandel

Sista …